New Paper: Multidrug-resistant E. coli encoding high genetic diversity in carbohydrate metabolism genes displace commensal E. coli from the intestinal tract

Congratulations to our Education & Mentorship Co-Lead Dr. Braedon McDonald on this recent publication! Abstract Extra-intestinal pathogenic Escherichia coli (ExPEC) can cause a variety of infections outside of the intestine and are a major causative agent of urinary tract infections. Treatment of these infections is increasingly frustrated by antimicrobial resistance (AMR) diminishing the number of effective therapies […]

New Paper: Metaproteomic Profiling of Fungal Gut Colonization in Gnotobiotic Mice

Congratulations to our Platform 2 Co-Lead Dr. Marie-Claire Arrieta on this recent publication! Abstract Eukaryotic microbes can modulate mammalian host health and disease states, yet the molecular contribution of gut fungi remains nascent. We previously showed that mice exclusively colonised with fungi displayed increased sensitivity to allergic airway inflammation and had fecal metabolite profiles similar […]

Exploring the Microbiome with @MediaplanetCA

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From health and disease to unravelling the Microbiome of extreme environments, this special campaign by Media Planet highlights cutting-edge and promising microbiome research and technical expertise across Canada. Notably featured is the International Microbiome Centre (IMC), based out of the University of Calgary and led by our IMPACTT Director Dr. Kathy McCoy. The IMC is […]

Protocol: Generation, Maintenance, and Monitoring of Gnotobiotic Mice

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Summary Gnotobiology has revolutionized the study of microbiota-host interactions. This protocol explains how to generate, maintain, and monitor gnotobiotic mice. Three monitoring methods are presented and compared: bacterial culture, microscopy to visualize the presence (or absence) of bacteria using Gram staining or DNA staining, and 16S rRNA gene amplification and sequencing. The generation and maintenance […]