New Paper: PSORTm : A Bacterial and Archaeal Protein Subcellular Localization Prediction Tool for Metagenomics Data
Congratulation to our Platform 5 Co-Lead Dr. Fiona Brinkman on this recent publication! Abstract We report PSORTm, the first bioinformatic tool designed for prediction of diverse bacterial and archaeal protein subcellular lo from metagenomics data. PSORTm incorporates components of PSORTb, one of the most precise and widely used protein SCL predictors, with an automated classification […]
New Paper: Open Data Revolution in Clinical Research: Opportunities and Challenges
Congratulations to our Ethics and Policy Lead Dr. Diego Silva on this recent publication! Abstract Efforts for sharing individual clinical data are gaining momentum due to a heightened recognition that integrated datasets can catalyze biomedical discoveries and drug development. Among the benefits are the fact that data sharing can help generate and investigate new research […]
New Paper: Maternal Psychological Distress Before Birth Influences Gut Immunity in Mid-Infancy
Congratulations to Platform 2 Lead Dr. Anita Kozyrskyj on this recent publication! Abstract Maternal pre‐postnatal psychosocial distress increases the risk for childhood allergic disease. This may occur through a host immunity pathway that involves intestinal secretory immunoglobulin A (sIgA). Experimental animal models show changes in the gut microbiome and immunity of offspring when exposed to […]
New Paper: Macrophage Galactose Lectin is Critical for Kupffer Cells to Clear Aged Platelets
Congratulations to Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract Early life exposure to microbes plays an important role in immune system development. Germ-free mice, or mice colonized with a low-diversity microbiota, exhibit high serum IgE levels. An increase in microbial richness, providing it occurs in a critical developmental window early in […]
New Paper: Using Precisely Defined In Vivo Microbiotas to Understand Microbial Regulation of IgE
Congratulations to IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy, Education & Mentorship Lead Dr. Markus Geuking, and Platform 4 Co-Lead Dr. Ian Lewis on this recent publication! Abstract Early life exposure to microbes plays an important role in immune system development. Germ-free mice, or mice colonized with a low-diversity microbiota, exhibit high serum […]
IMPACTT Sex & Gender Reading Pick
Sex: A change in our guidelines to authors to ensure that this is no longer an ignored variable An article by James R. Docherty et al., published 23 August 2019 in the British Journal of Pharmacology Communication from IMPACTT Sex & Gender Lead Dr. Jayne Danska At a time when precision medicine is a strategic […]
