New Paper: ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection Against Pulmonary Tuberculosis
Congratulations to Platform 1 Co-Lead Dr. Philippe Gros on this recent publication! Abstract We have used a genome-wide screen in N-ethyl-N-nitrosourea (ENU) mutagenized mice to identify genes in which recessive loss of function mutations protect against pathological neuroinflammation. We identified an R367Q mutation in the ZBTB7B (ThPOK) protein which homozygosity causes protection against experimental cerebral malaria […]
IMPACTT Director Dr. Kathy McCoy Shares Her Insights About Vaginal Seeding
This article is republished from The Conversation under a Creative Commons license. Read the original article here. Vaginal seeding has pros and cons… if you want to strengthen your baby’s microbiome, consider breastfeeding instead. DR. KATHY MCCOY What is ‘vaginal seeding’ and will it help your C-section baby? Should every baby born by caesarean section (C-section) be given […]
New Paper: Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion
Congratulations to Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract Bacterial biofilm infections are difficult to eradicate because of antibiotic insusceptibility and high recurrence rates. Biofilm formation by Pseudomonas aeruginosa, a leading cause of bacterial keratitis, is facilitated by the bacterial Psl exopolysaccharide and associated with heightened virulence. Using intravital microscopy, we […]
New Paper: Targeted Resequencing of Wetland Sediment as a Tool for Avian Influenza Virus Surveillance
Congratulation to Platform 5 Co-Lead Dr. William Hsiao on this recent publication! Abstract Surveillance methods for avian influenza virus (AIV) based upon collecting and testing samples from individual wild birds have several significant limitations primarily related to the difficulties associated with obtaining samples. Because AIVs are shed in waterfowl feces, the use of environmental substrates […]
New Paper: Microbiota-Derived Peptide Mimics Drive Lethal Inflammatory Cardiomyopathy
Congratulations to IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy, as well as Education & Mentorship Lead Dr. Markus Geuking, on this recent publication! Abstract Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6–specific T helper (TH)1 and TH17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T […]
New Paper: MDiNE: A Model to Estimate Differential Co-Occurrence Networks in Microbiome Studies
Congratulations to Dr. Celia Greenwood (Platform 5 Lead), Kevin McGregor et al.MDiNE is implemented in a freely available R package: https://github.com/kevinmcgregor/mdine MDiNE: A model to estimate differential co-occurrence networks in microbiome studies – Bioinformatics. 2019 Nov 7. PMID: 31697315 DOI: 10.1093/bioinformatics/btz824 Abstract We propose a new model called Microbiome Differential Network Estimation (MDiNE) to estimate network changes with respect […]
