New Paper: Long-term and trimester-specific effects of prenatal stress on the child gut microbiota
Congratulations to our Platform 2 Co-Lead Dr. Marie-Claire Arrieta on this recent publication! Abstract ObjectiveStress is common among pregnant individuals and is associated with an altered gut microbiota composition in infants. It is unknown if these compositional changes persist into the preschool years when the gut microbiota reaches an adult-like composition. This study aimed to […]
New Paper: Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
Congratulations to our Platform 2 Lead Dr. Anita Kozyrskyj on this recent publication! Abstract Allergic diseases affect millions of people worldwide. An increase in their prevalence has been associated with alterations in the gut microbiome, i.e., the microorganisms and their genes within the gastrointestinal tract. Maturation of the infant immune system and gut microbiota occur […]
New Paper: Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes and our IMPACTT Director/Platform 1 Lead Dr. Kathy McCoy on this recent publication! Abstract INTRODUCTION The local environment is critical for establishing the phenotype of macrophages within a given organ. In the liver, resident macrophages reach out of the sinusoids to receive instructive cues in a […]
New Paper: Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies
Congratulations to our Platform 2 Co-Lead Dr. Marie-Claire Arrieta on this recent publication! Abstract Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and placenta) are stably colonized by microbial communities in a healthy pregnancy remains a subject of debate. Here we evaluate recent studies that characterized microbial populations in human fetuses from […]
New Paper: Immunometabolism and microbial metabolites at the gut barrier: lessons for therapeutic intervention in Inflammatory Bowel Disease
Congratulations to our Platform 3 Lead Dr. Karen Madsen on this recent publication! Abstract The concept of immunometabolism has emerged recently whereby repolarizing of inflammatory immune cells towards anti-inflammatory profiles by manipulating cellular metabolism represents a new potential therapeutic approach in controlling inflammation. Metabolic pathways in immune cells are tightly regulated to maintain immune homeostasis and […]
New Paper: Long-Distance Relationships – Regulation of Systemic Host Defense Against Infections by the Gut Microbiota
Congratulations to our Education & Mentorship Leads Dr. Markus Geuking and Dr. Braedon McDonald on this recent publication! Abstract Despite compartmentalization within the lumen of the gastrointestinal tract, the gut microbiota has a far-reaching influence on immune cell development and function throughout the body. This long-distance relationship is crucial for immune homeostasis, including effective host […]
