New Paper: Is the Cure Worse than the Disease? The Ethics of Imposing Risk in Public Health
Congratulations to our Ethics Lead Dr. Diego Silva on this recent publication! Abstract Efforts to improve public health, both in the context of infectious diseases and non-communicable diseases, will often consist of measures that confer risk on some persons to bring about benefits to those same people or others. Still, it is unclear what exactly […]
New Paper: From Germ-Free to Wild: Modulating Microbiome Complexity to Understand Mucosal Immunology
Congratulations to our IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! Abstract The gut microbiota influences host responses at practically every level, and as research into host-microbe interactions expands, it is not surprising that we are uncovering similar roles for the microbiota at other barrier sites, such as the lung […]
New Paper: Moving Beyond Descriptive Studies: Harnessing Metabolomics to Elucidate the Molecular Mechanisms Underpinning Host-Microbiome Phenotypes
Congratulations to our Platform 2 Lead Dr. Anita Kozyrskyj & our Platform 4 Co-Lead Dr. Ian Lewis on this recent publication! Abstract Advances in technology and software have radically expanded the scope of metabolomics studies and allow us to monitor a broad transect of central carbon metabolism in routine studies. These increasingly sophisticated tools have […]
New Paper: Beta-Diversity Distance Matrices for Microbiome Sample Size and Power Calculations — How to Obtain Good Estimates
Congratulations to our IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy, as well as Platform 2 Leads Dr. Anita Kozyrskyj & Dr. Marie-Claire Arrieta, Platform 5 Lead Dr. Celia Greenwood, and Sex & Gender Lead Dr. Jayne Danska on this recent publication! Abstract In microbiome studies, researchers often wish to compare the taxa count distributions between […]
New Paper: Small Intestinal Resident Eosinophils Maintain Gut Homeostasis Following Microbial Colonization
Congratulations to our Education Leads Dr. Markus Geuking & Dr. Braedon McDonald, and IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy, on this recent publication! Abstract The intestine harbors a large population of resident eosinophils, yet the function of intestinal eosinophils has not been explored. Flow cytometry and whole-mount imaging identified eosinophils residing in the lamina […]
New Paper: The Rise to Power of the Microbiome: Power and Sample Size Calculation for Microbiome Studies
Congratulations to our Platform 2 Leads Dr. Marie-Claire Arrieta & Dr. Anita Kozyrskyj, and Platform 5 Lead Dr. Celia Greenwood, on this recent publication! Abstract A priori power and sample size calculations are crucial to appropriately test null hypotheses and obtain valid conclusions from all clinical studies. Statistical tests to evaluate hypotheses in microbiome studies […]
