New Paper: Ethical Health Security in the Age of Antimicrobial Resistance
Congratulations to our Ethics Lead Dr. Diego Silva on this recent publication! Abstract Owing to its potential human, social and economic costs, antimicrobial resistance (AMR) is frequently referred to as a threat to health security. Simultaneously, health security and the preservation of antimicrobials are often described as a global public good. However, how the term […]
New Paper: Metaproteomic Profiling of Fungal Gut Colonization in Gnotobiotic Mice
Congratulations to our Platform 2 Co-Lead Dr. Marie-Claire Arrieta on this recent publication! Abstract Eukaryotic microbes can modulate mammalian host health and disease states, yet the molecular contribution of gut fungi remains nascent. We previously showed that mice exclusively colonised with fungi displayed increased sensitivity to allergic airway inflammation and had fecal metabolite profiles similar […]
New Paper: Protease Activities of Vaginal Porphyromonas Species Disrupt Coagulation and Extracellular Matrix in the Cervicovaginal Niche
Congratulations to our Platform 4 Lead Dr. Laura Sycuro on this recent publication! Abstract Porphyromonas asaccharolytica and Porphyromonas uenonis are common inhabitants of the vaginal microbiome, but their presence has been linked to adverse health outcomes for women, including bacterial vaginosis and preterm birth. However, little is known about the pathogenesis mechanisms of these bacteria. The related oral […]
New Paper: Fecal Microbial Transplantation and Fiber Supplementation in Patients with Severe Obesity and Metabolic Syndrome
Congratulations to our Platform 3 Lead Dr. Karen Madsen on this recent publication! Abstract Fecal microbial transplantation (FMT) from lean donors to patients with obesity has been associated with metabolic benefits, yet results so far have been inconsistent. In this study, we tested the application of daily fiber supplementation as an adjunct to FMT therapy […]
New Paper: Bacteroides-Dominant Gut Microbiome of Late Infancy is Associated with Enhanced Neurodevelopment
Congratulations to our Platform 2 Lead Dr. Anita Kozyrskyj on this recent publication! In this longitudinal clinical study, the authors leveraged the CHILD cohort study by analyzing the gut microbiota of 405 infants at 4 months and 1 year of age. They revealed an association between the cognitive development of infants based on the presence […]
Protocol: Generation, Maintenance, and Monitoring of Gnotobiotic Mice
Summary Gnotobiology has revolutionized the study of microbiota-host interactions. This protocol explains how to generate, maintain, and monitor gnotobiotic mice. Three monitoring methods are presented and compared: bacterial culture, microscopy to visualize the presence (or absence) of bacteria using Gram staining or DNA staining, and 16S rRNA gene amplification and sequencing. The generation and maintenance […]
