New Paper: Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies
Congratulations to our Platform 2 Co-Lead Dr. Marie-Claire Arrieta on this recent publication! Abstract Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and placenta) are stably colonized by microbial communities in a healthy pregnancy remains a subject of debate. Here we evaluate recent studies that characterized microbial populations in human fetuses from […]
New Paper: Immunometabolism and microbial metabolites at the gut barrier: lessons for therapeutic intervention in Inflammatory Bowel Disease
Congratulations to our Platform 3 Lead Dr. Karen Madsen on this recent publication! Abstract The concept of immunometabolism has emerged recently whereby repolarizing of inflammatory immune cells towards anti-inflammatory profiles by manipulating cellular metabolism represents a new potential therapeutic approach in controlling inflammation. Metabolic pathways in immune cells are tightly regulated to maintain immune homeostasis and […]
New Paper: Long-Distance Relationships – Regulation of Systemic Host Defense Against Infections by the Gut Microbiota
Congratulations to our Education & Mentorship Leads Dr. Markus Geuking and Dr. Braedon McDonald on this recent publication! Abstract Despite compartmentalization within the lumen of the gastrointestinal tract, the gut microbiota has a far-reaching influence on immune cell development and function throughout the body. This long-distance relationship is crucial for immune homeostasis, including effective host […]
New Paper: From Germ-Free to Wild: Modulating Microbiome Complexity to Understand Mucosal Immunology
Congratulations to our IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! Abstract The gut microbiota influences host responses at practically every level, and as research into host-microbe interactions expands, it is not surprising that we are uncovering similar roles for the microbiota at other barrier sites, such as the lung […]
New Paper: Moving Beyond Descriptive Studies: Harnessing Metabolomics to Elucidate the Molecular Mechanisms Underpinning Host-Microbiome Phenotypes
Congratulations to our Platform 2 Lead Dr. Anita Kozyrskyj & our Platform 4 Co-Lead Dr. Ian Lewis on this recent publication! Abstract Advances in technology and software have radically expanded the scope of metabolomics studies and allow us to monitor a broad transect of central carbon metabolism in routine studies. These increasingly sophisticated tools have […]
New Paper: Beta-Diversity Distance Matrices for Microbiome Sample Size and Power Calculations — How to Obtain Good Estimates
Congratulations to our IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy, as well as Platform 2 Leads Dr. Anita Kozyrskyj & Dr. Marie-Claire Arrieta, Platform 5 Lead Dr. Celia Greenwood, and Sex & Gender Lead Dr. Jayne Danska on this recent publication! Abstract In microbiome studies, researchers often wish to compare the taxa count distributions between […]
