New Paper: ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection Against Pulmonary Tuberculosis
Congratulations to Platform 1 Co-Lead Dr. Philippe Gros on this recent publication! Abstract We have used a genome-wide screen in N-ethyl-N-nitrosourea (ENU) mutagenized mice to identify genes in which recessive loss of function mutations protect against pathological neuroinflammation. We identified an R367Q mutation in the ZBTB7B (ThPOK) protein which homozygosity causes protection against experimental cerebral malaria […]
New Paper: Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion
Congratulations to Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract Bacterial biofilm infections are difficult to eradicate because of antibiotic insusceptibility and high recurrence rates. Biofilm formation by Pseudomonas aeruginosa, a leading cause of bacterial keratitis, is facilitated by the bacterial Psl exopolysaccharide and associated with heightened virulence. Using intravital microscopy, we […]
New Paper: Microbiota-Derived Peptide Mimics Drive Lethal Inflammatory Cardiomyopathy
Congratulations to IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy, as well as Education & Mentorship Lead Dr. Markus Geuking, on this recent publication! Abstract Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6–specific T helper (TH)1 and TH17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T […]
