New Paper: Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes and our IMPACTT Director/Platform 1 Lead Dr. Kathy McCoy on this recent publication! Abstract INTRODUCTION The local environment is critical for establishing the phenotype of macrophages within a given organ. In the liver, resident macrophages reach out of the sinusoids to receive instructive cues in a […]
New Paper: Macrophage Galactose Lectin is Critical for Kupffer Cells to Clear Aged Platelets
Congratulations to Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract Early life exposure to microbes plays an important role in immune system development. Germ-free mice, or mice colonized with a low-diversity microbiota, exhibit high serum IgE levels. An increase in microbial richness, providing it occurs in a critical developmental window early in […]
Platform 1 | Gnotobiotic Animal Models and Intravital Microscopy
Platform 1 Gnotobiotic Animal Models & Intravital Microscopy Our Platform 1 Experts Dr. Kathy McCoy Dr. Paul Kubes Dr. Philippe Gros “We aim to provide robust precisely defined animal models that can fully interrogate host-microbiome interactions to advance microbiome research from association to causation and translate this knowledge into the clinic to improve human health.” […]
