Tune in: bacteria may hold a key to some cancer immunotherapies
In these two podcasts, our Director and Platform 1 Lead Dr. Kathy McCoy speaks about her recent study exploring the role of inosine, a bacterial metabolite, in response to cancer immunotherapies. Interviewer Charles Bergquist from Science Friday also raises some important questions such as the recent successes of the microbiome field (Twitter: @scifri). Richard Jacobs […]
New Paper: Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Using in vivo live imaging of infected lungs in animal models, Dr. Kubes‘ team and colleagues show that alveolar macrophages patrol the airways and capture inhaled bacteria, but their migration is impaired during viral infection. Their discoveries highlight the importance of finding […]
New Paper: Microbial Modulation of Intestinal T Helper Cell Responses and Implications for Disease and Therapy
Congratulations to our Education & Mentorship Lead Dr. Markus Geuking on this recent publication! This review summarizes the milestone findings in the field of microbiota-intestinal T helper cell crosstalk with a focus on the role of specific commensal bacteria and their metabolites. They discuss mechanistic mouse studies and are linking these to human studies where […]
New Paper: Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy, as well as our Education & Mentorship Lead & Co-Lead Dr. Markus Geuking and Dr. Braedon McDonald, on this recent publication! Summary Eradication of pathogens from the bloodstream is critical to prevent disseminated infections and sepsis. Kupffer cells in the liver form an intravascular […]
New Paper: Microbiome-Derived Inosine Modulates Response to Checkpoint Inhibitor Immunotherapy
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy, as well as our Platform 4 Co-Lead Dr. Ian Lewis and our Education & Mentorship Lead Dr. Markus Geuking, on this recent publication! Using an interdisciplinary approach, the authors identified three bacterial species that significantly enhanced the efficacy of immune checkpoint inhibitors in four […]
New Paper: Tacrolimus Impairs Kupffer Cell Capacity to Control Bacteremia: Why Transplant Recipients Are Susceptible to Infection
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Using a define mouse model of acute methicillin-resistant Staphylococcus aureus (MRSA) bacteremia along with intravital microscopy, Deppermann C, et al. unravelled why Tacrolimus, a drug used to prevent rejection in solid organ transplant recipients increases the susceptibility of transplant recipient to develop […]
