New Paper: Neutrophils Recirculate Through Lymph Nodes to Survey Tissues for Pathogens
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract The adaptive immune function of lymph nodes is dependent on constant recirculation of lymphocytes. In this article, we identify neutrophils present in the lymph node at steady state, exhibiting the same capacity for recirculation. In germ-free mice, neutrophils still recirculate through […]
New Paper: Macrophage Galactose Lectin is Critical for Kupffer Cells to Clear Aged Platelets
Congratulations to Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract Early life exposure to microbes plays an important role in immune system development. Germ-free mice, or mice colonized with a low-diversity microbiota, exhibit high serum IgE levels. An increase in microbial richness, providing it occurs in a critical developmental window early in […]
New Paper: Using Precisely Defined In Vivo Microbiotas to Understand Microbial Regulation of IgE
Congratulations to IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy, Education & Mentorship Lead Dr. Markus Geuking, and Platform 4 Co-Lead Dr. Ian Lewis on this recent publication! Abstract Early life exposure to microbes plays an important role in immune system development. Germ-free mice, or mice colonized with a low-diversity microbiota, exhibit high serum […]
New Paper: Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion
Congratulations to Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract Bacterial biofilm infections are difficult to eradicate because of antibiotic insusceptibility and high recurrence rates. Biofilm formation by Pseudomonas aeruginosa, a leading cause of bacterial keratitis, is facilitated by the bacterial Psl exopolysaccharide and associated with heightened virulence. Using intravital microscopy, we […]
