New Paper: Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy, as well as our Education & Mentorship Lead & Co-Lead Dr. Markus Geuking and Dr. Braedon McDonald, on this recent publication! Summary Eradication of pathogens from the bloodstream is critical to prevent disseminated infections and sepsis. Kupffer cells in the liver form an intravascular […]
New Paper: Microbiome-Derived Inosine Modulates Response to Checkpoint Inhibitor Immunotherapy
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy, as well as our Platform 4 Co-Lead Dr. Ian Lewis and our Education & Mentorship Lead Dr. Markus Geuking, on this recent publication! Using an interdisciplinary approach, the authors identified three bacterial species that significantly enhanced the efficacy of immune checkpoint inhibitors in four […]
New Paper: Vitamin D Supplementation in Pregnancy and Early Infancy in Relation to Gut Microbiota Composition and C. difficile Colonization: Implications for Viral Respiratory Infections
Congratulations to our Platform 2 Lead Dr. Anita Kozyrskyj on this recent publication! Studying 1,157 mother-infant pairs of the CHILD Cohort, researchers unravel a possible link between vitamin D supplementation during early-life and protection against C. difficile infection. Vit-D supplementation was also observed to be associated with a lower level of a specific bacterium Megamonas. […]
New Paper: Tacrolimus Impairs Kupffer Cell Capacity to Control Bacteremia: Why Transplant Recipients Are Susceptible to Infection
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Using a define mouse model of acute methicillin-resistant Staphylococcus aureus (MRSA) bacteremia along with intravital microscopy, Deppermann C, et al. unravelled why Tacrolimus, a drug used to prevent rejection in solid organ transplant recipients increases the susceptibility of transplant recipient to develop […]
New Paper: Mucosal or Systemic Microbiota Exposures Shape the B Cell Repertoire
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! In this intercontinental research effort between Switzerland, Norway, Germany and Canada, Dr. H. Li, colleagues and international collaborators notably Dr. K.D. McCoy, used “localized time-limited exposures of defined doses of single benign microbial taxa in germ-free mice” to “address how […]
New Paper: Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice
Congratulations to our Platform 3 Lead Dr. Karen Madsen on this recent publication! Using (IL)-10 deficient murine colitis model, Dr. Zhang et al. investigated whether the effects of isomaltodextrin (IMD) on gut microbiota and IBD were dependent on dose or host sex. Abstract There is growing interest in studying dietary fiber to stimulate microbiome changes […]
