New Paper: Immunological Roles of Intestinal Mesenchymal Cells
Congratulations to our IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! Abstract The intestine is continuously exposed to an enormous variety and quantity of antigens and innate immune stimuli derived from both pathogens and harmless materials, such as food and commensal bacteria. Accordingly, the intestinal immune system is uniquely adapted […]
New Paper: Clostridioides difficile Colonization Is Differentially Associated With Gut Microbiome Profiles by Infant Feeding Modality at 3–4 Months of Age
Congratulations to our Platform 2 Lead Dr. Anita Kozyrskyj on this recent publication! Abstract Colonization with Clostridioides difficile occurs in up to half of infants under the age of 3 months, is strongly influenced by feeding modality and is largely asymptomatic. In spite of this, C. difficile‘s presence has been associated with susceptibility to chronic disease later in […]
New Paper: Neutrophils Recirculate Through Lymph Nodes to Survey Tissues for Pathogens
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Abstract The adaptive immune function of lymph nodes is dependent on constant recirculation of lymphocytes. In this article, we identify neutrophils present in the lymph node at steady state, exhibiting the same capacity for recirculation. In germ-free mice, neutrophils still recirculate through […]
New Paper: PSORTm : A Bacterial and Archaeal Protein Subcellular Localization Prediction Tool for Metagenomics Data
Congratulation to our Platform 5 Co-Lead Dr. Fiona Brinkman on this recent publication! Abstract We report PSORTm, the first bioinformatic tool designed for prediction of diverse bacterial and archaeal protein subcellular lo from metagenomics data. PSORTm incorporates components of PSORTb, one of the most precise and widely used protein SCL predictors, with an automated classification […]
New Paper: Open Data Revolution in Clinical Research: Opportunities and Challenges
Congratulations to our Ethics and Policy Lead Dr. Diego Silva on this recent publication! Abstract Efforts for sharing individual clinical data are gaining momentum due to a heightened recognition that integrated datasets can catalyze biomedical discoveries and drug development. Among the benefits are the fact that data sharing can help generate and investigate new research […]
New Paper: Maternal Psychological Distress Before Birth Influences Gut Immunity in Mid-Infancy
Congratulations to Platform 2 Lead Dr. Anita Kozyrskyj on this recent publication! Abstract Maternal pre‐postnatal psychosocial distress increases the risk for childhood allergic disease. This may occur through a host immunity pathway that involves intestinal secretory immunoglobulin A (sIgA). Experimental animal models show changes in the gut microbiome and immunity of offspring when exposed to […]
