New Paper: Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases.
Study finds that artificially sweetened beverages consumption during pregnancy impacts mother’s microbiota and might lead to higher infant BMI.
The emerging roles of eosinophils in mucosal homeostasis.
A review of the critical role of eosinophils as regulators of mucosal homeostatic processes including immune maintenance, organ development and more.
New Paper: Simultaneous SNP Selection and Adjustment for Population Structure in High Dimensional Prediction Models
![Table 1. Simulation study results. Mean (standard deviation) from 200 simulations stratified by the number of causal SNPs (null, 1%), the overlap between causal SNPs and kinship matrix (no overlap, all causal SNPs in kinship), and true heritability (10%, 30%). For all simulations, sample size is n = 1000, the number of covariates is p = 5000, and the number of SNPs used to estimate the kinship matrix is k = 10000. TPR at FPR = 5% is the true positive rate at a fixed false positive rate of 5%. Model Size () is the number of selected variables in the training set using the high-dimensional BIC for ggmix and 10-fold cross validation for lasso and twostep. RMSE is the root mean squared error on the test set. Estimation error is the squared distance between the estimated and true effect sizes. Error variance (σ2) for twostep is estimated from an intercept only LMM with a single random effect and is modeled explicitly in ggmix. For the lasso we use [28] as an estimator for σ2. Heritability (η) for twostep is estimated as from an intercept only LMM with a single random effect where and are the variance components for the random effect and error term, respectively. η is explictly modeled in ggmix. There is no positive way to calculate η for the lasso since we are using a PC adjustment. show less](https://i0.wp.com/www.impactt-microbiome.ca/wp-content/uploads/2020/05/journal.pgen_.1008766.t001.png?fit=800%2C443&ssl=1)
ggmix, general penalized linear mixed effects model with a single random effect for simultaneous SNP selection and adjustment for population structure in high dimensional prediction models.
New Paper: Immunological Roles of Intestinal Mesenchymal Cells
Congratulations to our IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! Abstract The intestine is continuously exposed to an enormous variety and quantity of antigens and innate immune stimuli derived from both pathogens and harmless materials, such as food and commensal bacteria. Accordingly, the intestinal immune system is uniquely adapted […]
New Book: Microbiota in Health and Disease: From Pregnancy to Childhood
In 2017, Editors Pamela D. Browne, Eric Claassen and Michael D. Cabana published a book about the Microbiota in health and disease: from pregnancy to childhood in Wageningen Academic Publishers. Microbiota in health and disease: from pregnancy to childhood aims to provide a state-of-the-art overview in the field of infant and child microbiota and their role in health, […]
Perspective: Maternal Microbiota in Pregnancy and Early Life
Congratulations to our IMPACTT Director and Platform 1 Lead Dr. Kathy McCoy and our Education Co-Lead Dr. Braedon McDonald on this publication! McDonald B, McCoy KD. Maternal microbiota in pregnancy and early life. Science. 2019;365(6457):984-985. doi:10.1126/science.aay0618Science 06 Sep 2019 Abstract A microbial bond is shared between mother and child that renders the age-old dichotomy of “nature versus […]
