Congratulations to our Ethics and Policy Lead Dr. Diego Silva on this recent publication!
Abstract
Efforts for sharing individual clinical data are gaining momentum due to a heightened recognition that integrated datasets can catalyze biomedical discoveries and drug development. Among the benefits are the fact that data sharing can help generate and investigate new research hypothesis beyond those explored in the original study. Despite several accomplishments establishing public systems and guidance for data sharing in clinical trials, this practice is not the norm. Among the reasons are ethical challenges, such as privacy of individuals, data ownership, and control. This manuscript creates awareness of the potential benefits and challenges of sharing individual clinical data, how to overcome these challenges, and how as a clinical pharmacology community we can shape future directions in this field
Despite improved mood postpartum and independent of breastfeeding status, mothers experiencing antepartum depressive symptoms delivered offspring who exhibited lower fecal sIgA concentrations especially in later infancy. The implications of lowered sIgA concentrations in infant stool are altered microbe‐sIgA interactions, greater risk for C difficile colonization and atopic disease in later years.
Publication:Open Data Revolution in Clinical Research: Opportunities and Challenges. Shahin MH, Bhattacharya S, Silva D, Kim S, Burton J, Peodichetty J, Romero K, Conrado DJ. Clinical and Translational Science. 31 January 2020.
