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General Microbiome
Pregnancy & Early Life
Health & Disease
Antimicrobial Resistance
Microbiome & Immunity

General Microbiome

Documentary: Let Them Eat Dirt

Dr. Brett Finlay and Dr. Marie-Claire Arrieta (IMPACTT Platform 2 Co-Lead) have written an engaging and important book called Let Them Eat Dirt: Saving our Children

Video: Host-Microbe-Environment Interactions

Over the past few years, evidence has revealed the key role that microbes play in human health and disease. This short animated video highlights key

Role and Impact of the Microbiome on the Human Genome

Read about key concepts and views on the role and impact of our microbes’ genomes on our human genome! 3 recent papers to give you

New Paper: The Hygiene Hypothesis, the COVID Pandemic, and Consequences for the Human Microbiome

Congratulations to our Platform 1 Co-Lead Dr. Philippe Gros on this recent publication! A perspective from the Canadian Institute for Advanced Research (CIFAR) on the impact

Green spaces may be beneficial for early life microbiota, be outdoorsy!

Analyzing and mapping the microbiota of 355 4 month-old infants to their area of living, Dr. Kozyrskyj and her colleagues revealed that living close by

New Paper: Intestinal Fungi are Causally Implicated in Microbiome Assembly and Immune Development in Mice

Intestinal fungi are causally implicated in microbiome assembly and immune development in mice.

Fig 1. The perinatal period represents a time in development when exogenous factors that affect the microbiome such as antibiotics, diet, hygiene, pathogens, mode of birth, and pollutants can alter immune and physiological programming. The effects of early-life programming may lead to increased disease susceptibility later in life. Created with BioRender.com from The impact of maternal and early life malnutrition on health: a diet-microbe perspective.

The impact of maternal and early life malnutrition on health: a diet-microbe perspective.

Provide an overview of factors implicated in the progression of malnutrition during early life, discuss the microbiota that may contribute to health risk.

Fig 3. Drivers of gut bacterial beta-diversity and indicator taxa associated with maternal consumption of ASB differ between clusters. (A) Univariate models showing significance and explained variance of 10 variables on bacterial community structure across all data and each cluster subset. Horizontal bars show the amount of variance (R2) explained by each covariate in the model as determined by envfit. Asterisk denotes the significant covariates in each data subset (P

New Paper: Consumption of Artificially Sweetened Beverages During Pregnancy Impacts Infant Gut Microbiota and Body Mass Index

Study finds that artificially sweetened beverages consumption during pregnancy impacts mother’s microbiota and might lead to higher infant BMI.

Fig5.b.Decreasing-antibiotic-use-the-gut-microbiota-and-asthma-incidence-in-children-evidence-from-population-based-and-prospective-cohort-studies

New Paper: Decreasing Antibiotic Use, The Gut Microbiota, and Asthma Incidence in Children: Evidence From Population-Based and Prospective Cohort Studies

The authors investigated if the decreases in asthma incidence are linked to reduced antibiotic prescribing and mediated by changes in the gut microbiota.

Illustration about the effect of diet on the microbiota

New Paper: A Diversified Dietary Pattern Is Associated With a Balanced Gut Microbial Composition of Faecalibacterium and Escherichia/Shigella in Patients With Crohn’s Disease in Remission

Study the relationships between dietary intake and shifts in microbiota and their metabolites in Crohn’s Disease patients to help define a dietary pattern.

New Paper: Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases.

Study finds that artificially sweetened beverages consumption during pregnancy impacts mother’s microbiota and might lead to higher infant BMI.

New Paper: Maternal Distress During Pregnancy and Recurrence in Early Childhood Predicts Atopic Dermatitis and Asthma in Childhood

This population-based study shows sex-specific associations between maternal prenatal and postnatal distress, as well as the development of AD and asthma.

Microbiome & Immunity

Gut microbes shape our antibodies before we are infected by pathogens - Gut-Flora-Illustration

New Paper: Mucosal or Systemic Microbiota Exposures Shape the B Cell Repertoire

Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! In this intercontinental research effort between Switzerland, Norway, Germany and

Figure 1. Experimental design. https://pubmed.ncbi.nlm.nih.gov/32679670/

New Paper: Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice

Congratulations to our Platform 3 Lead Dr. Karen Madsen on this recent publication! Using (IL)-10 deficient murine colitis model, Dr. Zhang et al. investigated whether

New Paper: Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases.

Study finds that artificially sweetened beverages consumption during pregnancy impacts mother’s microbiota and might lead to higher infant BMI.

Fig 3. Gut microbiota affects the distribution and morphology of intestinal CX3CR1+ macrophages from the article Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome

New Paper: Perivascular Localization of Macrophages in the Intestinal Mucosa is Regulated by Nr4a1 and the Microbiome

A review of the critical role of eosinophils as regulators of mucosal homeostatic processes including immune maintenance, organ development and more.

Resources By Topic