Platform 1 | Resources
Platform 1 Resources Keep scrolling for posts and pages related to our Platform 1 on Gnotobiotic Animals & Intravital Microscopy. Related Posts Related Pages
The 4 Core Genotype Model
The 4 Core Genotype (4CG) Model This murine model enables researchers to distinguish sex hormone effects from sex chromosome effects in their research. Below is a description of the characteristics of this model. The 4CG model will soon be made available under gnotobiotic conditions at the International Microbiome Centre in Calgary upon request. Request the […]
New Paper: Innate Responses to Gut Microbiota; Critical Assessment of the Necessary Experimental Controls
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy on this recent publication! Focusing on the recent findings (since 2017) regarding the commensal bacteria of the mouse intestinal tract, Dr. McCoy and Dr. Ohland discuss the importance and advances of what experimental controls are required to reliably determine how the microbiota influences the […]
Tune in: bacteria may hold a key to some cancer immunotherapies
In these two podcasts, our Director and Platform 1 Lead Dr. Kathy McCoy speaks about her recent study exploring the role of inosine, a bacterial metabolite, in response to cancer immunotherapies. Interviewer Charles Bergquist from Science Friday also raises some important questions such as the recent successes of the microbiome field (Twitter: @scifri). Richard Jacobs […]
New Paper: Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis
Congratulations to our Platform 1 Co-Lead Dr. Paul Kubes on this recent publication! Using in vivo live imaging of infected lungs in animal models, Dr. Kubes‘ team and colleagues show that alveolar macrophages patrol the airways and capture inhaled bacteria, but their migration is impaired during viral infection. Their discoveries highlight the importance of finding […]
New Paper: Microbiome-Derived Inosine Modulates Response to Checkpoint Inhibitor Immunotherapy
Congratulations to our Director and Platform 1 Lead Dr. Kathy McCoy, as well as our Platform 4 Co-Lead Dr. Ian Lewis and our Education & Mentorship Lead Dr. Markus Geuking, on this recent publication! Using an interdisciplinary approach, the authors identified three bacterial species that significantly enhanced the efficacy of immune checkpoint inhibitors in four […]
